High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
نویسندگان
چکیده
منابع مشابه
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The nuclear protein high mobility group box protein 1 (HMGB1) promotes inflammation upon extracellular release. HMGB1 induces proinflammatory cytokine production in macrophages via Toll-like receptor (TLR)-4 signaling in a redox-dependent fashion. Independent of its redox state and endogenous cytokine-inducing ability, HMGB1 can form highly immunostimulatory complexes by interaction with certai...
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High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. To function as an alarmin, HMGB1 translocates f...
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High mobility group box 1(HMGB1), originally described as a DNA-binding protein, can also be released extracellularly and functions as a late mediator of inflammatory responses. Although recent reports indicated that the receptor for advanced glycation endproducts (RAGE), as well as Toll-like receptors (TLR2 and TLR4), were involved in cellular activation by HMGB1, there has been little evidenc...
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High-mobility group box 1 (HMGB1; also known as amphoterin) protein was identified more than 30 years ago as a non-chromosomal nuclear protein that maintains the nucleosome structure and regulates gene transcription. HMGB1 is highly conserved among species, has over 98% identity among all mammals, and is ubiquitously expressed in almost all types of cells. HMGB1-deficient mice are viable but di...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2015
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2015.00087